Lysosomal membrane permeabilization during apoptosis - involvement of Bax?
نویسندگان
چکیده
منابع مشابه
Mitochondrial shape governs BAX-induced membrane permeabilization and apoptosis.
Proapoptotic BCL-2 proteins converge upon the outer mitochondrial membrane (OMM) to promote mitochondrial outer membrane permeabilization (MOMP) and apoptosis. Here we investigated the mechanistic relationship between mitochondrial shape and MOMP and provide evidence that BAX requires a distinct mitochondrial size to induce MOMP. We utilized the terminal unfolded protein response pathway to sys...
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The tumor suppressor p53 exerts its anti-neoplastic activity primarily through the induction of apoptosis. We found that cytosolic localization of endogenous wild-type or trans-activation-deficient p53 was necessary and sufficient for apoptosis. p53 directly activated the proapoptotic Bcl-2 protein Bax in the absence of other proteins to permeabilize mitochondria and engage the apoptotic progra...
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ژورنال
عنوان ژورنال: International Journal of Experimental Pathology
سال: 2005
ISSN: 0959-9673
DOI: 10.1111/j.0959-9673.2005.00442.x